Detail Information
P450 Protein:
| P450 Symbol | ankB |
| Protein Name | Cytochrome P450 monooxygenase ankB (EC 1.-.-.-) (Ank biosynthesis cluster protein B) |
| Uniprot ID | A0A397HSG2 |
| EC Number | 1.-.-.- |
| Species | Aspergillus thermomutatus (Neosartorya pseudofischeri) |
| Txid | 41047 |
| P450 Protein Structure |
Model Confidence (pLDDT)
Very high (>90)
High (90 > 70)
Low (70 > 50)
Very low (<50)
|
| Subcellular Location | |
| Protein Sequence | GO |
Reaction Scheme:
| Chemical Conversion | C15H22N5O3+ + C17H21N4O9P-2 + O2 → C15H20N5O3+ + C17H18N4O9P-3 + H2O + H+ |
| Reaction Type | Oxidation |
| Chemical Bond | CH |
| RheaID | 80207 |
+
+
ankB
+
+
+
Substrate Information:
| Substrate Name | cyclo(L-arginyl-tyrosyl) |
| Substrate Chemical Formula | C15H22N5O3+ |
| Substrate PubChem CID | 171666188 |
| Substrate Smiles | C1=CC(=CC=C1CC2C(=O)NC(C(=O)N2)CCC[NH+]=C(N)N)O |
| Substrate Structure |
| Substrate Name | FMNH2 |
| Substrate Chemical Formula | C17H21N4O9P-2 |
| Substrate PubChem CID | 44229161 |
| Substrate Smiles | CC1=CC2=C(C=C1C)N(C3=C(N2)C(=O)NC(=O)N3)C[C@@H]([C@@H]([C@@H](COP(=O)([O-])[O-])O)O)O |
| Substrate Structure |
| Substrate Name | O2 |
| Substrate Chemical Formula | O2 |
| Substrate PubChem CID | 977 |
| Substrate CAS Number | 7782-44-7 |
| Substrate Smiles | O=O |
| Substrate Structure |
Product Information:
| Product Name | cyclo(L-arginyl-L-dehydrotyrosyl) |
| Product Chemical Formula | C15H20N5O3+ |
| Product PubChem CID | 171364930 |
| Product Smiles | C1=CC(=CC=C1C=C2C(=O)NC(C(=O)N2)CCC[NH+]=C(N)N)O |
| Product Structure |
| Product Name | FMN |
| Product Chemical Formula | C17H18N4O9P-3 |
| Product PubChem CID | 44229199 |
| Product Smiles | CC1=CC2=C(C=C1C)N(C3=NC(=NC(=O)C3=N2)[O-])C[C@@H]([C@@H]([C@@H](COP(=O)([O-])[O-])O)O)O |
| Product Structure |
| Product Name | H2O |
| Product Chemical Formula | H2O |
| Product PubChem CID | 962 |
| Product CAS Number | 7732-18-5 |
| Product Smiles | O |
| Product Structure |
| Product Name | H+ |
| Product Chemical Formula | H+ |
| Product PubChem CID | 1038 |
| Product CAS Number | 12408-02-5 |
| Product Smiles | [H+] |
| Product Structure |
References:
| Title: | Draft Genome Sequence of Azole-Resistant Aspergillus thermomutatus (Neosartorya pseudofischeri) Strain HMR-AF-39, Isolated from a Human Nasal Septum Abscess Aspirate. |
| PMID: | 30637395 |
| Journal: | Microbiology resource announcements |
| Year: | 2019/1/ |
| Title: | Genome mining for unknown-unknown natural products. |
| PMID: | 36702957 |
| Journal: | Nature chemical biology |
| Year: | 2023/5/ |