Detail Information
P450 Protein:
| P450 Symbol | CYP719A37 |
| Protein Name | Piperic acid synthase CYP719A37 (EC 1.14.19.-) (Cytochrome P450 dependent monooxygenase 719A37) (PnCYP719) |
| Uniprot ID | A0A7T9QPT0 |
| EC Number | 1.14.19.- |
| Species | Piper nigrum (Black pepper) |
| Txid | 13216 |
| P450 Protein Structure |
Model Confidence (pLDDT)
Very high (>90)
High (90 > 70)
Low (70 > 50)
Very low (<50)
|
| Subcellular Location | |
| Protein Sequence | GO |
Reaction Scheme:
| Chemical Conversion | C12H11O4- + C17H21N4O9P-2 + O2 → C12H9O4- + C17H18N4O9P-3 + H2O + H+ |
| Reaction Type | Redox |
| Chemical Bond | |
| RheaID | 73555 |
+
+
CYP719A37
+
+
+
Substrate Information:
| Substrate Name | (E,E)-feruperate |
| Substrate Chemical Formula | C12H11O4- |
| Substrate PubChem CID | 165368659 |
| Substrate Smiles | COC1=C(C=CC(=C1)C=CC=CC(=O)O)[O-] |
| Substrate Structure |
| Substrate Name | FMNH2 |
| Substrate Chemical Formula | C17H21N4O9P-2 |
| Substrate PubChem CID | 44229161 |
| Substrate Smiles | CC1=CC2=C(C=C1C)N(C3=C(N2)C(=O)NC(=O)N3)C[C@@H]([C@@H]([C@@H](COP(=O)([O-])[O-])O)O)O |
| Substrate Structure |
| Substrate Name | O2 |
| Substrate Chemical Formula | O2 |
| Substrate PubChem CID | 977 |
| Substrate CAS Number | 7782-44-7 |
| Substrate Smiles | O=O |
| Substrate Structure |
Product Information:
| Product Name | (E,E)-piperate |
| Product Chemical Formula | C12H9O4- |
| Product PubChem CID | 22182051 |
| Product Smiles | C1OC2=C(O1)C=C(C=C2)C=CC=CC(=O)[O-] |
| Product Structure |
| Product Name | FMN |
| Product Chemical Formula | C17H18N4O9P-3 |
| Product PubChem CID | 44229199 |
| Product Smiles | CC1=CC2=C(C=C1C)N(C3=NC(=NC(=O)C3=N2)[O-])C[C@@H]([C@@H]([C@@H](COP(=O)([O-])[O-])O)O)O |
| Product Structure |
| Product Name | H2O |
| Product Chemical Formula | H2O |
| Product PubChem CID | 962 |
| Product CAS Number | 7732-18-5 |
| Product Smiles | O |
| Product Structure |
| Product Name | H+ |
| Product Chemical Formula | H+ |
| Product PubChem CID | 1038 |
| Product CAS Number | 12408-02-5 |
| Product Smiles | [H+] |
| Product Structure |
References:
| Title: | Piper nigrum CYP719A37 Catalyzes the Decisive Methylenedioxy Bridge Formation in Piperine Biosynthesis. |
| PMID: | 33435446 |
| Journal: | Plants (Basel, Switzerland) |
| Year: | 2021/1/9 |