Detail Information
P450 Protein:
| P450 Symbol | flvD |
| Protein Name | Cytochrome P450 monooxygenase flvD (EC 1.-.-.-) (Flavunoidine biosynthesis cluster protein D) |
| Uniprot ID | B8NHD9 |
| EC Number | 1.-.-.- |
| Species | Aspergillus flavus (strain ATCC 200026 / FGSC A1120 / IAM 13836 / NRRL 3357 / JCM 12722 / SRRC 167) |
| Txid | 332952 |
| P450 Protein Structure |
Model Confidence (pLDDT)
Very high (>90)
High (90 > 70)
Low (70 > 50)
Very low (<50)
|
| Subcellular Location | |
| Protein Sequence | GO |
Reaction Scheme:
| Chemical Conversion | C15H24 + C17H21N4O9P-2 + O2 → C15H23O+ + C17H18N4O9P-3 + H2O + H+ |
| Reaction Type | Oxidation |
| Chemical Bond | CH |
| RheaID | 77075 |
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flvD
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+
Substrate Information:
| Substrate Name | (1R,4R,5S)-acoradiene |
| Substrate Chemical Formula | C15H24 |
| Substrate PubChem CID | 13743810 |
| Substrate Smiles | C[C@@H]1CC[C@@H]([C@]12CCC(=CC2)C)C(=C)C |
| Substrate Structure |
| Substrate Name | FMNH2 |
| Substrate Chemical Formula | C17H21N4O9P-2 |
| Substrate PubChem CID | 44229161 |
| Substrate Smiles | CC1=CC2=C(C=C1C)N(C3=C(N2)C(=O)NC(=O)N3)C[C@@H]([C@@H]([C@@H](COP(=O)([O-])[O-])O)O)O |
| Substrate Structure |
| Substrate Name | O2 |
| Substrate Chemical Formula | O2 |
| Substrate PubChem CID | 977 |
| Substrate CAS Number | 7782-44-7 |
| Substrate Smiles | O=O |
| Substrate Structure |
Product Information:
| Product Name | 2,6,9-trimethyl-13-oxatetracyclo[6.3.1.1(6,9).0(1,5)]tridecane carbocation |
| Product Chemical Formula | C15H23O+ |
| Product PubChem CID | 168475472 |
| Product Smiles | CC1CCC2C13CCC4(C(C3)[CH+]C2(O4)C)C |
| Product Structure |
| Product Name | FMN |
| Product Chemical Formula | C17H18N4O9P-3 |
| Product PubChem CID | 44229199 |
| Product Smiles | CC1=CC2=C(C=C1C)N(C3=NC(=NC(=O)C3=N2)[O-])C[C@@H]([C@@H]([C@@H](COP(=O)([O-])[O-])O)O)O |
| Product Structure |
| Product Name | H2O |
| Product Chemical Formula | H2O |
| Product PubChem CID | 962 |
| Product CAS Number | 7732-18-5 |
| Product Smiles | O |
| Product Structure |
| Product Name | H+ |
| Product Chemical Formula | H+ |
| Product PubChem CID | 1038 |
| Product CAS Number | 12408-02-5 |
| Product Smiles | [H+] |
| Product Structure |
References:
| Title: | Genome Sequence of Aspergillus flavus NRRL 3357, a Strain That Causes Aflatoxin Contamination of Food and Feed. |
| PMID: | 25883274 |
| Journal: | Journal of the American Chemical Society |
| Year: | 2020/1/15 |
| Title: | Genome Mining of Alkaloidal Terpenoids from a Hybrid Terpene and Nonribosomal Peptide Biosynthetic Pathway. |
| PMID: | 31885262 |
| Journal: | Genome announcements |
| Year: | 2015/4/16 |