Detail Information
P450 Protein:
| P450 Symbol | cyp521A1 |
| Protein Name | Cytochrome P450 monooxygenase 521A1 (EC 1.14.-.-) (Discodiene biosynthesis cluster protein cyp521A1) |
| Uniprot ID | Q1ZXA1 |
| EC Number | 1.14.-.- |
| Gene ID | 8629378 |
| Species | Dictyostelium discoideum (Social amoeba) |
| Txid | 44689 |
| P450 Protein Structure |
Model Confidence (pLDDT)
Very high (>90)
High (90 > 70)
Low (70 > 50)
Very low (<50)
|
| Subcellular Location | |
| Protein Sequence | GO |
Reaction Scheme:
| Chemical Conversion | C15H26O + C17H21N4O9P-2 + O2 → C12H18 + C3H6O + C17H18N4O9P-3 + H2O + H+ |
| Reaction Type | Redox |
| Chemical Bond | C-C |
| RheaID | 74107 |
+
+
cyp521A1
+
+
+
+
Substrate Information:
| Substrate Name | discoidol |
| Substrate Chemical Formula | C15H26O |
| Substrate PubChem CID | 165368663 |
| Substrate Smiles | CC1CCCC2=CCC(CC12C)C(C)(C)O |
| Substrate Structure |
| Substrate Name | FMNH2 |
| Substrate Chemical Formula | C17H21N4O9P-2 |
| Substrate PubChem CID | 44229161 |
| Substrate Smiles | CC1=CC2=C(C=C1C)N(C3=C(N2)C(=O)NC(=O)N3)C[C@@H]([C@@H]([C@@H](COP(=O)([O-])[O-])O)O)O |
| Substrate Structure |
| Substrate Name | O2 |
| Substrate Chemical Formula | O2 |
| Substrate PubChem CID | 977 |
| Substrate CAS Number | 7782-44-7 |
| Substrate Smiles | O=O |
| Substrate Structure |
Product Information:
| Product Name | discodiene |
| Product Chemical Formula | C12H18 |
| Product PubChem CID | 165368653 |
| Product Smiles | CC1CCCC2=CC=CCC12C |
| Product Structure |
| Product Name | acetone |
| Product Chemical Formula | C3H6O |
| Product PubChem CID | 180 |
| Product CAS Number | 67-64-1 |
| Product Smiles | CC(=O)C |
| Product Structure |
| Product Name | FMNH2 |
| Product Chemical Formula | C17H18N4O9P-3 |
| Product PubChem CID | 44229199 |
| Product Smiles | CC1=CC2=C(C=C1C)N(C3=NC(=NC(=O)C3=N2)[O-])C[C@@H]([C@@H]([C@@H](COP(=O)([O-])[O-])O)O)O |
| Product Structure |
| Product Name | H2O |
| Product Chemical Formula | H2O |
| Product PubChem CID | 962 |
| Product CAS Number | 7732-18-5 |
| Product Smiles | O |
| Product Structure |
| Product Name | H+ |
| Product Chemical Formula | H+ |
| Product PubChem CID | 1038 |
| Product CAS Number | 12408-02-5 |
| Product Smiles | [H+] |
| Product Structure |
References:
| Title: | The genome of the social amoeba Dictyostelium discoideum. |
| PMID: | 15875012 |
| Journal: | eLife |
| Year: | 2019/5/7 |
| Title: | A terpene synthase-cytochrome P450 cluster in Dictyostelium discoideum produces a novel trisnorsesquiterpene. |
| PMID: | 31063135 |
| Journal: | Nature |
| Year: | 2005/5/5 |