Detail Information
P450 Protein:
| P450 Symbol | CYP82D213 |
| Protein Name | Cytochrome P450 82D213 variant |
| Uniprot ID | |
| Species | Tripterygium wilfordii |
| Txid | 458696 |
| P450 Protein Structure |
Model Confidence (pLDDT)
Very high (>90)
High (90 > 70)
Low (70 > 50)
Very low (<50)
|
| Subcellular Location | |
| Protein Sequence | GO |
Reaction Scheme:
| Chemical Conversion | C20H24O3 → C20H22O6 |
| Reaction Type | Oxidation |
| Chemical Bond | C=C;CH;C-OH |
CYP82D213
Substrate Information:
| Substrate Name | Triptophenolide |
| Substrate Chemical Formula | C20H24O3 |
| Substrate PubChem CID | 173273 |
| Substrate CAS Number | 74285-86-2 |
| Substrate Smiles | CC(C)C1=C(C2=C(C=C1)[C@]3(CCC4=C([C@@H]3CC2)COC4=O)C)O |
| Substrate Structure |
Product Information:
| Product Name | Triptonide |
| Product Chemical Formula | C20H22O6 |
| Product PubChem CID | 65411 |
| Product CAS Number | 38647-11-9 |
| Product Smiles | CC(C)[C@@]12[C@@H](O1)[C@H]3[C@@]4(O3)[C@]5(CCC6=C([C@@H]5C[C@H]7[C@]4(C2=O)O7)COC6=O)C |
| Product Structure |
References:
| Title: | Structure-guided engineering of CYP82D213 for enhanced triptonide biosynthesis |
| PMID: | 41713248 |
| Journal: | Enzyme and microbial technology |
| Year: | 2026/2/14 |