Detail Information

P450 Protein:

P450 Symbol	CYP75A109
Protein Name	cytochrome P450 family 75 subfamily A polypeptide 109
Uniprot ID
Species	Gloriosa superba (Glory lily)
Txid	41220
P450 Protein Structure	Go to AlphaFold Website Model Confidence (pLDDT) Very high (>90) High (90 > 70) Low (70 > 50) Very low (<50) Powered by PDBe Molstar & AlphaFold
Subcellular Location
Protein Sequence	GO
Remarks	GenBank:QLI49053.1

Reaction Scheme:

(1S)-1-[2-(4-hydroxyphenyl)ethyl]-6-methoxy-2-methyl-3,4-dihydro-1H-isoquinolin-7-ol

CYP75A109

4-{2-[(1S)-7-hydroxy-6-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-1-yl]ethyl}benzene-1,2-diol

Substrate Information:

Substrate Name	(1S)-1-[2-(4-hydroxyphenyl)ethyl]-6-methoxy-2-methyl-3,4-dihydro-1H-isoquinolin-7-ol
Substrate Chemical Formula	C19H23NO3
Substrate PubChem CID	7055395
Substrate Smiles	CN1CCC2=CC(=C(C=C2[C@@H]1CCC3=CC=C(C=C3)O)O)OC
Substrate Structure	Download SDF

Product Information:

Product Name	4-{2-[(1S)-7-hydroxy-6-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-1-yl]ethyl}benzene-1,2-diol
Product Chemical Formula	C19H23NO4
Product Smiles	C(OC)1C=C2CCN(C)[C@@H](CCC3C=C(O)C(O)=CC=3)C2=CC=1O
Product Structure	Download SDF

References:

Title:	Puzzling Out the Colchicine Biosynthetic Pathway
PMID:	33166069
Journal:	ChemMedChem
Year:	2020/11/9