Detail Information
P450 Protein:
| P450 Symbol | CYP75A109 |
| Protein Name | cytochrome P450 family 75 subfamily A polypeptide 109 |
| Uniprot ID | |
| Species | Gloriosa superba (Glory lily) |
| Txid | 41220 |
| P450 Protein Structure |
Model Confidence (pLDDT)
Very high (>90)
High (90 > 70)
Low (70 > 50)
Very low (<50)
|
| Subcellular Location | |
| Protein Sequence | GO |
| Remarks | GenBank:QLI49053.1 |
Reaction Scheme:
| Chemical Conversion | C19H23NO4 → C20H25NO5 |
| Reaction Type | Oxidation |
| Chemical Bond | CH;OH |
CYP75A109
Substrate Information:
| Substrate Name | 4-{2-[(1S)-7-hydroxy-6-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-1-yl]ethyl}benzene-1,2-diol |
| Substrate Chemical Formula | C19H23NO4 |
| Substrate Smiles | C(OC)1C=C2CCN(C)[C@@H](CCC3C=C(O)C(O)=CC=3)C2=CC=1O |
| Substrate Structure |
Product Information:
| Product Name | 5-{2-[(1S)-7-hydroxy-6-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-1-yl]ethyl}-3-methoxybenzene-1,2-diol |
| Product Chemical Formula | C20H25NO5 |
| Product Smiles | C(OC)1C=C2CCN(C)[C@@H](CCC3C=C(OC)C(O)=C(O)C=3)C2=CC=1O |
| Product Structure |
References:
| Title: | Puzzling Out the Colchicine Biosynthetic Pathway |
| PMID: | 33166069 |
| Journal: | ChemMedChem |
| Year: | 2020/11/9 |