Detail Information
P450 Protein:
| P450 Symbol | CYP75A110 |
| Protein Name | cytochrome P450 family 75 subfamily A polypeptide 110 |
| Uniprot ID | |
| Species | Gloriosa superba (Glory lily) |
| Txid | 41220 |
| P450 Protein Structure |
Model Confidence (pLDDT)
Very high (>90)
High (90 > 70)
Low (70 > 50)
Very low (<50)
|
| Subcellular Location | |
| Protein Sequence | GO |
| Remarks | GenBank:QLI49056.1 |
Reaction Scheme:
| Chemical Conversion | C21H27NO5 → C21H25NO5 |
| Reaction Type | Oxidative Cyclization |
| Chemical Bond | C-C;C-N;OH |
CYP75A110
Substrate Information:
| Substrate Name | (S)-autumnaline |
| Substrate Chemical Formula | C21H27NO5 |
| Substrate PubChem CID | 13878324 |
| Substrate CAS Number | 23068-65-7 |
| Substrate Smiles | CN1CCC2=CC(=C(C=C2[C@@H]1CCC3=CC(=C(C(=C3)OC)OC)O)O)OC |
| Substrate Structure |
Product Information:
| Product Name | Isoandrocymbine |
| Product Chemical Formula | C21H25NO5 |
| Product PubChem CID | 46173814 |
| Product Smiles | CN1CC[C@@]23C=C(C(=O)C=C2[C@@H]1CCC4=CC(=C(C(=C34)OC)OC)O)OC |
| Product Structure |
References:
| Title: | Puzzling Out the Colchicine Biosynthetic Pathway |
| PMID: | 33166069 |
| Journal: | ChemMedChem |
| Year: | 2020/11/9 |