Detail Information
P450 Protein:
| P450 Symbol | CYP105A1 |
| Protein Name | Vitamin D3 dihydroxylase |
| Uniprot ID | P18326 |
| EC Number | 1.14.15.22 |
| Species | Streptomyces griseolus |
| Txid | 1909 |
| P450 Protein Structure |
Model Confidence (pLDDT)
Very high (>90)
High (90 > 70)
Low (70 > 50)
Very low (<50)
|
| Subcellular Location | |
| Protein Sequence | GO |
Reaction Scheme:
| Chemical Conversion | C13H20O → C13H18O2 |
| Reaction Type | Oxidation |
| Chemical Bond | CH |
| Conditions | 2 d, 25°C |
| Transformations | 1. Hydroxylation at an Aliphatic Carbon |
CYP105A1
Substrate Information:
| Substrate Name | Beta-Ionone |
| Substrate Chemical Formula | C13H20O |
| Substrate PubChem CID | 638014 |
| Substrate CAS Number | 79-77-6 |
| Substrate Smiles | CC1=C(C(CCC1)(C)C)C=CC(=O)C |
| Substrate Structure |
Product Information:
| Product Name | 2,4,4-Trimethyl-3-[(1E)-3-oxo-1-buten-1-yl]-2-cyclohexen-1-one |
| Product Chemical Formula | C13H18O2 |
| Product PubChem CID | 5363876 |
| Product CAS Number | 29790-29-2 |
| Product Smiles | O=C(C=CC1=C(C(=O)CCC1(C)C)C)C |
| Product Structure |
References:
| Title: | Efficient terpene hydroxylation catalysts based upon P450 enzymes derived from actinomycetes. |
| PMID: | 16186924 |
| Journal: | Organic & Biomolecular Chemistry (2005) |
| Year: | 2005/7/7 |